Abstract
The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist -Adam- which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge.
| Original language | English |
|---|---|
| Pages (from-to) | 85-89 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 324 |
| Issue number | 5923 |
| DOIs | |
| Publication status | Published - 3 Apr 2009 |
Access to Document
POST-PEER-REVIEW-PUBLISHERS.PDFFinal published version, 623 KB
Other files and links
SUPPLEMENTARY-1.PDF
Fingerprint
Dive into the research topics of 'The automation of science'. Together they form a unique fingerprint.
View full fingerprint
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
King, R. D., Rowland, J., Oliver, S. G., Young, M., Aubrey, W., Byrne, E., Liakata, M., Markham, M., Pir, P., Soldatova, L. N., Sparkes, A., Whelan, K. E., & Clare, A. (2009). The automation of science. Science, 324(5923), 85-89. https://doi.org/10.1126/science.1165620
King, Ross D. ; Rowland, Jem ; Oliver, Stephen G. et al. / The automation of science. In: Science. 2009 ; Vol. 324, No. 5923. pp. 85-89.
@article{953b64bb8e2a443488204c0c23fe602d,
title = "The automation of science",
abstract = "The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist -Adam- which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge.",
author = "King, {Ross D.} and Jem Rowland and Oliver, {Stephen G.} and Michael Young and Wayne Aubrey and Emma Byrne and Maria Liakata and Magdalena Markham and Pinar Pir and Soldatova, {Larisa N.} and Andrew Sparkes and Whelan, {Kenneth E.} and Amanda Clare",
year = "2009",
month = apr,
day = "3",
doi = "10.1126/science.1165620",
language = "English",
volume = "324",
pages = "85--89",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science (A A A S)",
number = "5923",
}
King, RD, Rowland, J, Oliver, SG, Young, M, Aubrey, W, Byrne, E, Liakata, M, Markham, M, Pir, P, Soldatova, LN, Sparkes, A, Whelan, KE & Clare, A 2009, 'The automation of science', Science, vol. 324, no. 5923, pp. 85-89. https://doi.org/10.1126/science.1165620
The automation of science. / King, Ross D.; Rowland, Jem; Oliver, Stephen G. et al.
In: Science, Vol. 324, No. 5923, 03.04.2009, p. 85-89.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - The automation of science
AU - King, Ross D.
AU - Rowland, Jem
AU - Oliver, Stephen G.
AU - Young, Michael
AU - Aubrey, Wayne
AU - Byrne, Emma
AU - Liakata, Maria
AU - Markham, Magdalena
AU - Pir, Pinar
AU - Soldatova, Larisa N.
AU - Sparkes, Andrew
AU - Whelan, Kenneth E.
AU - Clare, Amanda
PY - 2009/4/3
Y1 - 2009/4/3
N2 - The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist -Adam- which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge.
AB - The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist -Adam- which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge.
U2 - 10.1126/science.1165620
DO - 10.1126/science.1165620
M3 - Article
SN - 0036-8075
VL - 324
SP - 85
EP - 89
JO - Science
JF - Science
IS - 5923
ER -
King RD, Rowland J, Oliver SG, Young M, Aubrey W, Byrne E et al. The automation of science. Science. 2009 Apr 3;324(5923):85-89. doi: 10.1126/science.1165620
